Last updated: March 2026
How Much Does Tysabri (Natalizumab) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Tysabri 300mg IV Infusion | $7,500 – $9,500 | $500 – $3,000 |
| Tysabri SC (Subcutaneous) | $7,500 – $9,500 | $500 – $3,000 |
CPT/ADA Code: J2323
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Specialty tier — IV infusion every 4 weeks; TOUCH prescribing program required
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Tysabri costs $7,500 to $9,500 per infusion without insurance, given every 4 weeks, totaling approximately $100,000+ per year.
TOUCH is a mandatory safety program because Tysabri carries a risk of PML, a rare brain infection. Patients and providers must be enrolled.
Tysabri is one of the most effective MS treatments, reducing relapses by about 68%. It is typically reserved for patients who have not responded to other therapies.