Last updated: March 2026
How Much Does Tizanidine Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Tizanidine 2mg (generic) | $4 – $10 | $0 – $4 |
| Tizanidine 4mg (generic) | $4 – $15 | $0 – $6 |
| Tizanidine 4mg Capsule (generic) | $6 – $20 | $1 – $8 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Tier 1 generic — centrally-acting muscle relaxant for spasticity
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Generic tizanidine costs $4 to $20 per month without insurance. It is available on most $4 generic programs.
Tizanidine (Zanaflex) treats muscle spasticity from conditions like multiple sclerosis, spinal cord injury, and cerebral palsy. It is also used off-label for tension headaches and muscle spasm.
Yes, significant drowsiness is common. Tizanidine also lowers blood pressure and can cause dry mouth. Many patients take it at bedtime to manage sedation.