Last updated: March 2026
How Much Does Tacrolimus Ointment (Protopic) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Tacrolimus 0.03% Ointment (generic, 30g) | $30 – $80 | $10 – $25 |
| Tacrolimus 0.1% Ointment (generic, 30g) | $35 – $100 | $10 – $30 |
| Protopic 0.1% Ointment (brand, 60g) | $150 – $200 | $25 – $40 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Tier 2–3 — covered for eczema; prior authorization may be required; step therapy common
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Generic tacrolimus ointment costs $30 to $100 for a 30g tube. Brand-name Protopic is $150 to $200 without insurance.
Tacrolimus is a non-steroidal immunomodulator used to treat moderate-to-severe eczema (atopic dermatitis). It is especially useful for sensitive areas where steroids are not recommended.
Yes, tacrolimus is one of the preferred treatments for facial eczema because it does not cause the skin thinning associated with topical steroids. The 0.03% strength is approved for children 2 and older.