Last updated: March 2026
How Much Does Sertraline (Zoloft) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Sertraline 50mg (30 tablets) | $4 – $15 | $0 – $5 |
| Sertraline 100mg (30 tablets) | $4 – $20 | $0 – $5 |
| Sertraline 200mg (30 tablets) | $6 – $25 | $0 – $10 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Tier 1 generic — $0-$10 copay
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
$4-$25 for a 30-day supply. It's on Walmart's $4 list and available for under $10 with GoodRx at most pharmacies.
Yes — sertraline is FDA-approved for panic disorder, social anxiety, PTSD, and OCD in addition to depression. It's one of the most prescribed antidepressants.
Most people notice improvement in 2-4 weeks. Full effect may take 6-8 weeks. Don't stop without your doctor's guidance.