Last updated: March 2026
How Much Does Progesterone (Prometrium/Cream) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| 100-200mg Oral Capsules Generic (30-day) | $20 – $80 | $5 – $20 |
| Compounded Progesterone Cream | $30 – $80 | $10 – $30 |
| Vaginal Suppository/Insert (Endometrin) | $200 – $500 | $30 – $80 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Oral generic Tier 2; compounded cream varies
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Progesterone supports pregnancy, treats irregular periods, prevents endometrial hyperplasia in women on estrogen therapy, and is used in fertility treatments.
Generic oral progesterone costs $20 to $80/month. Compounded creams cost $30 to $80. Vaginal inserts cost $200 to $500.
OTC progesterone creams have variable absorption and are not FDA-regulated. Prescription oral or vaginal progesterone is more reliable.