Last updated: March 2026
How Much Does Progesterone (Prometrium) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Progesterone 100mg Capsule | $15 – $30 | $3 – $10 |
| Progesterone 200mg Capsule | $20 – $50 | $5 – $15 |
| Progesterone Vaginal Insert | $30 – $80 | $10 – $30 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Tier 1–2 generic — covered by most plans; often prescribed with estrogen therapy
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Generic progesterone capsules cost between $15 and $50 for a 30-day supply without insurance. Brand-name Prometrium is typically more expensive.
Progesterone is prescribed alongside estrogen in women with a uterus to protect against endometrial hyperplasia and cancer that unopposed estrogen can cause.
Common side effects include drowsiness, dizziness, breast tenderness, headache, and mood changes. Taking the capsule at bedtime can help with drowsiness.