Last updated: March 2026
How Much Does Ondansetron (Zofran) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Ondansetron 4mg Tablet | $4 – $12 | $0 – $5 |
| Ondansetron 8mg Tablet | $6 – $20 | $0 – $8 |
| Ondansetron ODT (Dissolving Tablet) | $8 – $25 | $2 – $10 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Tier 1 generic — widely covered; quantity limits may apply
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Generic ondansetron costs between $4 and $20 for a typical prescription without insurance. Prices vary by dosage and tablet count.
Ondansetron is an anti-nausea medication used to prevent nausea and vomiting caused by surgery, chemotherapy, or radiation therapy. It is also commonly prescribed for gastroenteritis.
Ondansetron is sometimes prescribed for severe morning sickness, but its safety in pregnancy is debated. Discuss risks and benefits with your healthcare provider.