Last updated: March 2026
How Much Does Ocrevus (Ocrelizumab) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Ocrevus Initial Dose (300mg x2) | $16,000 – $20,000 | $1,000 – $5,000 |
| Ocrevus Maintenance (600mg) | $32,000 – $40,000 | $2,000 – $8,000 |
CPT/ADA Code: J2350
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Specialty tier — IV infusion every 6 months; prior authorization required
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Ocrevus costs $16,000 to $20,000 per initial infusion and $32,000 to $40,000 per maintenance infusion every 6 months without insurance.
Ocrevus treats relapsing and primary progressive forms of multiple sclerosis (MS). It is one of few treatments approved for primary progressive MS.
Yes, the Ocrevus Co-pay Program may reduce out-of-pocket costs significantly for eligible commercially insured patients.