Last updated: March 2026
How Much Does Naproxen (Prescription) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Naproxen 250mg (generic Rx) | $4 – $10 | $0 – $4 |
| Naproxen 500mg (generic Rx) | $4 – $12 | $0 – $5 |
| Naproxen DR 500mg (generic) | $6 – $15 | $1 – $6 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Tier 1 generic — prescription-strength NSAID; also available OTC at lower doses
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Prescription-strength naproxen costs $4 to $15 per month without insurance. OTC naproxen (Aleve) at 220mg is typically $8-$15 for a bottle, making a prescription often cheaper for regular use.
Yes, prescription naproxen comes in 250mg and 500mg tablets, while OTC Aleve is 220mg. Your doctor may prescribe the higher dose for significant arthritis or inflammatory pain.
Naproxen may have a slightly lower cardiovascular risk than other NSAIDs, making it a preferred choice for patients with heart disease risk factors. However, all NSAIDs carry similar GI and kidney risks.