Last updated: March 2026
How Much Does Mirtazapine Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Mirtazapine 15mg (generic) | $4 – $12 | $0 – $5 |
| Mirtazapine 30mg (generic) | $4 – $15 | $0 – $6 |
| Mirtazapine 45mg (generic) | $6 – $20 | $1 – $8 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Tier 1 generic — antidepressant that also helps with insomnia and appetite stimulation
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Generic mirtazapine costs $4 to $20 per month without insurance. It is available on most $4 generic programs.
Yes, mirtazapine is very sedating, especially at lower doses (15mg), making it useful for patients with depression accompanied by insomnia. Paradoxically, it may be less sedating at higher doses.
Yes, significant weight gain and increased appetite are among the most common side effects of mirtazapine. This can be therapeutic for patients with depression-related weight loss or poor appetite.