Last updated: March 2026
How Much Does Mesalamine (Asacol/Lialda) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Mesalamine DR 800mg Tablet (generic) | $100 – $250 | $20 – $60 |
| Mesalamine DR 1.2g Tablet (Lialda) | $300 – $500 | $50 – $100 |
| Mesalamine Rectal Suppository | $80 – $200 | $15 – $50 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Tier 2–3 — prior authorization may be required; brand vs generic cost difference significant
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Mesalamine costs between $100 and $500 per month without insurance depending on the formulation. Generic delayed-release tablets are the most affordable option.
Mesalamine is an anti-inflammatory drug used to treat and maintain remission of ulcerative colitis and mild-to-moderate Crohn's disease.
Yes, generic mesalamine delayed-release tablets are available at significant savings compared to brand names like Asacol HD and Lialda.