Last updated: March 2026
How Much Does Linezolid (Zyvox) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Linezolid 600mg Generic Tablet | $100 – $400 | $20 – $100 |
| Zyvox 600mg (brand) | $2,500 – $3,000 | $200 – $500 |
| Linezolid 600mg IV (generic) | $80 – $300 | $15 – $80 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Tier 3 — oral/IV antibiotic for resistant infections; generic available but still expensive
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Generic linezolid costs $100 to $400 for a course of treatment. Brand Zyvox is dramatically more expensive at $2,500 to $3,000. Total costs depend on treatment duration, which can be 10-28 days.
Linezolid treats serious MRSA infections, vancomycin-resistant enterococcus (VRE), and other drug-resistant gram-positive infections including pneumonia and skin infections.
Linezolid can cause bone marrow suppression (low blood counts), peripheral neuropathy, and serotonin syndrome when combined with serotonergic drugs. Treatment is typically limited to 28 days.