Last updated: March 2026
How Much Does Imbruvica (Ibrutinib) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Imbruvica 420mg (CLL dose) | $14,000 – $17,000 | $800 – $4,500 |
| Imbruvica 560mg (MCL dose) | $14,000 – $17,000 | $800 – $4,500 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Specialty tier — oral cancer medication; prior authorization required
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Imbruvica costs $14,000 to $17,000 per month without insurance. It is taken daily as a continuous therapy.
Imbruvica treats chronic lymphocytic leukemia (CLL), mantle cell lymphoma, Waldenstrom's macroglobulinemia, and chronic graft-versus-host disease.
Medicare Part D covers Imbruvica, but patients may face significant out-of-pocket costs during the coverage gap. Manufacturer assistance programs are available.