Last updated: March 2026
How Much Does Hepatitis B Vaccine Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Engerix-B (3-dose series) | $50 – $100 | $0 – $0 |
| Heplisav-B (2-dose series) | $100 – $200 | $0 – $0 |
| Twinrix (Hep A+B combo) | $100 – $180 | $0 – $0 |
CPT/ADA Code: 90746
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Preventive care — covered at no cost for recommended groups under ACA plans; three-dose series
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Each dose costs $50 to $200 without insurance depending on the vaccine type. The complete series (2-3 doses) costs $100 to $400.
Traditional hepatitis B vaccines require 3 doses over 6 months. The newer Heplisav-B requires only 2 doses one month apart.
The CDC recommends hepatitis B vaccination for all infants, unvaccinated adults through age 59, and adults 60+ with risk factors.