Last updated: March 2026
How Much Does Filgrastim (Neupogen) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| 300mcg Prefilled Syringe (Brand) | $500 – $3,000 | $50 – $400 |
| 300mcg Biosimilar (Zarxio) | $300 – $1,500 | $30 – $250 |
| 480mcg Prefilled Syringe | $600 – $3,500 | $60 – $500 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Specialty tier; covered under medical benefit; biosimilars preferred
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Filgrastim stimulates white blood cell production and is used after chemotherapy to reduce infection risk (neutropenia) and for stem cell mobilization.
Brand Neupogen costs $500 to $3,000 per injection. Biosimilar Zarxio costs $300 to $1,500, offering significant savings.
Filgrastim is typically given daily for 5 to 14 days starting 24 hours after chemotherapy until white blood cell counts recover.