Last updated: March 2026
How Much Does Ezetimibe Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Ezetimibe 10mg (generic) | $8 – $20 | $2 – $8 |
| Zetia 10mg (brand) | $200 – $300 | $25 – $60 |
| Ezetimibe-Simvastatin 10/40mg (generic combo) | $15 – $40 | $5 – $15 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Tier 1-2 generic — cholesterol absorption inhibitor; often combined with a statin
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Generic ezetimibe costs $8 to $30 per month without insurance. The brand name Zetia is much more expensive at $200 to $300 per month.
Yes, ezetimibe is often prescribed alongside a statin for additional LDL cholesterol reduction of 15-25%. The IMPROVE-IT trial showed cardiovascular benefits from this combination.
Ezetimibe works in the small intestine by blocking the absorption of dietary and biliary cholesterol. This mechanism is different from statins, making them complementary when used together.