Last updated: March 2026
How Much Does Entyvio (Vedolizumab) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Entyvio IV Infusion 300mg | $5,000 – $7,000 | $500 – $2,000 |
| Entyvio SC 108mg (self-injection) | $4,500 – $6,000 | $400 – $1,800 |
CPT/ADA Code: J3380
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Specialty tier — prior authorization required; IV infusion or subcutaneous
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Entyvio IV infusion costs $5,000 to $7,000 per treatment without insurance. Infusions are given at weeks 0, 2, 6, then every 8 weeks.
Entyvio treats moderate-to-severe ulcerative colitis and Crohn's disease. It targets the gut specifically rather than suppressing the entire immune system.
Yes, Entyvio SC is a self-injectable option for maintenance therapy after initial IV loading doses, offering more convenience.