Last updated: March 2026
How Much Does Entacapone (Comtan) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| 200mg Tablets Generic (30-day) | $30 – $100 | $5 – $25 |
| Stalevo (levodopa/carbidopa/entacapone combo) | $60 – $150 | $10 – $30 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Covered as Tier 2 generic; used as add-on to levodopa
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Entacapone extends the effect of levodopa-carbidopa in Parkinson's disease by blocking the enzyme that breaks down levodopa (COMT inhibitor).
Generic entacapone costs $30 to $100/month. The combination pill Stalevo costs $60 to $150/month but is more convenient.
Entacapone is added when patients experience 'wearing off' between levodopa doses, typically in mid-to-advanced Parkinson's disease.