Last updated: March 2026
How Much Does Denosumab (Prolia) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| 60mg Subcutaneous Injection (every 6 months) | $1,000 – $2,500 | $30 – $300 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Tier 4-5 specialty; often covered under medical benefit with prior auth
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Prolia costs $1,000 to $2,500 per injection given every 6 months. Annual cost is $2,000 to $5,000 without insurance.
Most insurance plans cover Prolia with prior authorization, especially after bisphosphonate failure. Medicare Part B covers it as a medical benefit.
No. Stopping Prolia abruptly can cause rapid bone loss and increased fracture risk. Your doctor should transition you to another medication.