Last updated: March 2026
How Much Does Cyclosporine Eye Drops (Restasis) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Cyclosporine 0.05% (Restasis, 30 vials) | $350 – $500 | $50 – $80 |
| Cyclosporine 0.09% (Cequa, 60 vials) | $400 – $550 | $50 – $80 |
| Cyclosporine 0.05% (generic, 30 vials) | $200 – $350 | $30 – $60 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Tier 3 — prior authorization typically required; step therapy through artificial tears first
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Brand-name Restasis costs $350 to $500 per month. Generic cyclosporine eye drops cost $200 to $350 without insurance.
Cyclosporine eye drops treat chronic dry eye disease by reducing inflammation and helping the eyes produce more natural tears over time.
Cyclosporine eye drops typically take 3 to 6 months to show full benefit. Some patients notice improvement within 4 to 8 weeks. Consistent twice-daily use is essential.