Last updated: March 2026
How Much Does Cyclosporine (Neoral/Sandimmune) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| 25mg Capsules Generic (30-day) | $50 – $150 | $10 – $35 |
| 100mg Capsules Generic (30-day) | $100 – $350 | $20 – $60 |
| Oral Solution 100mg/mL (50mL) | $80 – $250 | $15 – $50 |
| Ophthalmic Emulsion (Restasis) | $200 – $500 | $30 – $80 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Tier 2-3 generic; brand may require prior auth
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Cyclosporine prevents transplant rejection and treats severe autoimmune diseases including psoriasis, rheumatoid arthritis, and dry eye (Restasis).
Cyclosporine levels, kidney function, blood pressure, and other labs must be monitored regularly due to risks of nephrotoxicity and drug interactions.
Generic oral cyclosporine costs $50 to $350/month depending on the dose. Restasis eye drops cost $200 to $500/month.