Last updated: March 2026
How Much Does Byetta (Exenatide) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Byetta 5mcg Pen | $600 – $800 | $25 – $250 |
| Byetta 10mcg Pen | $650 – $850 | $25 – $250 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Brand — twice-daily GLP-1 injection; prior authorization may be required
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Byetta costs $600 to $850 per month without insurance. It is one of the older GLP-1 medications.
Byetta is injected twice daily, within 60 minutes before morning and evening meals. This is more frequent than newer weekly GLP-1 options.
Yes, Bydureon is a once-weekly extended-release version of the same drug (exenatide) for more convenient dosing.