Last updated: March 2026
How Much Does Bupropion for Smoking Cessation (Zyban) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| 150mg SR Tablets Generic (30-day) | $15 – $40 | $0 – $10 |
| 150mg SR Tablets Generic (60-day course) | $25 – $80 | $0 – $15 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Generic Tier 1; ACA requires $0 coverage for cessation
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Same medication, different indication. Zyban (bupropion SR) is for smoking cessation; Wellbutrin is for depression. Generic bupropion SR is used for both.
Generic bupropion SR costs $15 to $40/month. Under the ACA, it should be covered at $0 with a prescription for smoking cessation.
Start 1 to 2 weeks before your quit date. Take 150mg once daily for 3 days, then 150mg twice daily for 7 to 12 weeks.