Last updated: March 2026
How Much Does Aspirin Rx (Prescription Strength) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| Aspirin 81mg EC Tablet (Rx, 90ct) | $4 – $8 | $0 – $3 |
| Aspirin 325mg Tablet (Rx) | $4 – $10 | $0 – $5 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Tier 1 generic — covered on most plans; OTC versions widely available
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Prescription aspirin costs $4 to $10 for a 90-day supply. OTC aspirin is similarly priced but a prescription may provide insurance coverage.
A prescription allows insurance coverage (potentially lower cost), documents the medical necessity for daily aspirin therapy, and ensures proper dosing for cardiovascular prevention.
Low-dose aspirin (81mg daily) is commonly used for cardiovascular prevention. The 2022 USPSTF guidelines narrowed recommendations — discuss with your doctor whether daily aspirin is right for you.