Last updated: March 2026
How Much Does Allopurinol (Zyloprim) Cost?
Cost Breakdown by Type
| Type / Procedure | Without Insurance | With Insurance |
|---|---|---|
| 100mg Tablets (30-day) | $8 – $20 | $0 – $8 |
| 300mg Tablets (30-day) | $10 – $30 | $0 – $10 |
What Affects the Cost
- Brand-name vs. generic availability
- Insurance formulary tier placement
- Pharmacy choice (retail vs. mail-order vs. Costco)
- Manufacturer savings cards and coupons
- Dosage and quantity prescribed
- Geographic location
Insurance Coverage
Typical coverage: Covered as Tier 1 generic; first-line urate-lowering therapy
Most insurance plans use a tiered formulary: Tier 1 (generic) $0-$15 copay, Tier 2 (preferred brand) $25-$75, Tier 3 (non-preferred brand) $50-$150, Tier 4 (specialty) $100-$500+. Prior authorization may be required for certain medications. Step therapy may require trying cheaper alternatives first.
How to Save Money
- Always ask for generic when available — saves 50-90%
- Use GoodRx, RxSaver, or similar discount cards
- Costco pharmacy is open to non-members and often has lowest prices
- Mark Cuban's Cost Plus Drugs offers transparent low pricing
- Manufacturer patient assistance programs provide free medication to qualifying patients
- HSA/FSA funds can cover medication costs tax-free
Related Procedures & Costs
Frequently Asked Questions
Generic allopurinol is very affordable at $8 to $30 per month, making it one of the cheapest chronic disease medications.
Allopurinol lowers uric acid levels over weeks, but it takes 3 to 6 months to fully prevent gout attacks. Flares may increase initially.
If already taking allopurinol, continue it during an attack. Do not start it during an acute flare; wait until the attack resolves.